Morphological Changes in the Lacrimal Gland of Anophthalmic Socket in Relation to the Contralateral Normal Eye in Male Wistar Albino Rats: A Histopathology Study (2023)

Shashidhar, D., Thangarajan, R., Theruveethi, N., & Bonkuri, S. (2021). Morphological Changes in the Lacrimal Gland of Anophthalmic Socket in Relation to the Contralateral Normal Eye in Male Wistar Albino Rats: A Histopathology Study. Current Eye Research, 46(12), 1816-1821. https://doi.org/10.1080/02713683.2021.1945107

Shashidhar, Dantapuram ; Thangarajan, Rajesh ; Theruveethi, Nagarajan et al. / Morphological Changes in the Lacrimal Gland of Anophthalmic Socket in Relation to the Contralateral Normal Eye in Male Wistar Albino Rats : A Histopathology Study. In: Current Eye Research. 2021 ; Vol. 46, No. 12. pp. 1816-1821.

@article{a08d5744dc514e328a0be6550f2a9002,

title = "Morphological Changes in the Lacrimal Gland of Anophthalmic Socket in Relation to the Contralateral Normal Eye in Male Wistar Albino Rats: A Histopathology Study",

abstract = "Purpose: The purpose of the study is to analyze the structural and functional alterations of the lacrimal gland and its tear secretion post-enucleation in Wistar rats. Method: Adult male Wistar rats (n=15) of 8-week-old were randomly assigned into three groups viz. control, sham, and experimental group (n=5). Rats of the experimental group were subjected to enucleation of the right eye. Under aseptic surgical conditions, with sterilized forceps, right eyeball of the rats of experimental group was exposed completely out of the socket by applying pressure on the lateral canthus of the eye. Enucleation was then achieved after holding the optic nerve tightly. The surgical procedure was similar in sham group without enucleation. Quantity of tears (Basal and reflex) secreted in both eyes in rats of all groups were measured by using Schirmer{\textquoteright}s strip, pre- and post-three weeks of enucleation. The lacrimal gland was harvested to analyze histopathological (structural) alterations. Results: Pr- and post-enucleation there was no significant difference observed in the tear volume across the groups. Histopathology of the lacrimal glands from all groups showed preserved lobular architecture with serous acini arranged in lobules, intralobular and interlobular ducts, interstitial fibro collagenous tissue. There was no glandular distortion and atrophy in experimental group. Conclusion: Enucleation do not co-relate or affect the tear volume and lacrimal gland acinar microstructural changes in an anophthalmic socket co-relating to the contralateral normal functional eye.",

author = "Dantapuram Shashidhar and Rajesh Thangarajan and Nagarajan Theruveethi and Subhashini Bonkuri",

note = "Funding Information: We, authors, thank Manipal Academy of Higher Education for supporting research work financially. Funding Information: Authors declare the sources of study funding were provided by the Manipal Academy of Higher Education (MAHE), Manipal [Seed money ID 00000281]. We, authors, thank Manipal Academy of Higher Education for supporting research work financially. Publisher Copyright: {\textcopyright} 2021 Taylor & Francis Group, LLC.",

year = "2021",

doi = "10.1080/02713683.2021.1945107",

language = "English",

volume = "46",

pages = "1816--1821",

journal = "Current Eye Research",

issn = "0271-3683",

publisher = "Informa Healthcare",

number = "12",

}

Shashidhar, D, Thangarajan, R, Theruveethi, N & Bonkuri, S 2021, 'Morphological Changes in the Lacrimal Gland of Anophthalmic Socket in Relation to the Contralateral Normal Eye in Male Wistar Albino Rats: A Histopathology Study', Current Eye Research, vol. 46, no. 12, pp. 1816-1821. https://doi.org/10.1080/02713683.2021.1945107

Morphological Changes in the Lacrimal Gland of Anophthalmic Socket in Relation to the Contralateral Normal Eye in Male Wistar Albino Rats : A Histopathology Study. / Shashidhar, Dantapuram; Thangarajan, Rajesh; Theruveethi, Nagarajan et al.

In: Current Eye Research, Vol. 46, No. 12, 2021, p. 1816-1821.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Morphological Changes in the Lacrimal Gland of Anophthalmic Socket in Relation to the Contralateral Normal Eye in Male Wistar Albino Rats

T2 - A Histopathology Study

AU - Shashidhar, Dantapuram

AU - Thangarajan, Rajesh

AU - Theruveethi, Nagarajan

AU - Bonkuri, Subhashini

N1 - Funding Information:We, authors, thank Manipal Academy of Higher Education for supporting research work financially. Funding Information:Authors declare the sources of study funding were provided by the Manipal Academy of Higher Education (MAHE), Manipal [Seed money ID 00000281]. We, authors, thank Manipal Academy of Higher Education for supporting research work financially.Publisher Copyright:© 2021 Taylor & Francis Group, LLC.

PY - 2021

Y1 - 2021

N2 - Purpose: The purpose of the study is to analyze the structural and functional alterations of the lacrimal gland and its tear secretion post-enucleation in Wistar rats. Method: Adult male Wistar rats (n=15) of 8-week-old were randomly assigned into three groups viz. control, sham, and experimental group (n=5). Rats of the experimental group were subjected to enucleation of the right eye. Under aseptic surgical conditions, with sterilized forceps, right eyeball of the rats of experimental group was exposed completely out of the socket by applying pressure on the lateral canthus of the eye. Enucleation was then achieved after holding the optic nerve tightly. The surgical procedure was similar in sham group without enucleation. Quantity of tears (Basal and reflex) secreted in both eyes in rats of all groups were measured by using Schirmer’s strip, pre- and post-three weeks of enucleation. The lacrimal gland was harvested to analyze histopathological (structural) alterations. Results: Pr- and post-enucleation there was no significant difference observed in the tear volume across the groups. Histopathology of the lacrimal glands from all groups showed preserved lobular architecture with serous acini arranged in lobules, intralobular and interlobular ducts, interstitial fibro collagenous tissue. There was no glandular distortion and atrophy in experimental group. Conclusion: Enucleation do not co-relate or affect the tear volume and lacrimal gland acinar microstructural changes in an anophthalmic socket co-relating to the contralateral normal functional eye.

AB - Purpose: The purpose of the study is to analyze the structural and functional alterations of the lacrimal gland and its tear secretion post-enucleation in Wistar rats. Method: Adult male Wistar rats (n=15) of 8-week-old were randomly assigned into three groups viz. control, sham, and experimental group (n=5). Rats of the experimental group were subjected to enucleation of the right eye. Under aseptic surgical conditions, with sterilized forceps, right eyeball of the rats of experimental group was exposed completely out of the socket by applying pressure on the lateral canthus of the eye. Enucleation was then achieved after holding the optic nerve tightly. The surgical procedure was similar in sham group without enucleation. Quantity of tears (Basal and reflex) secreted in both eyes in rats of all groups were measured by using Schirmer’s strip, pre- and post-three weeks of enucleation. The lacrimal gland was harvested to analyze histopathological (structural) alterations. Results: Pr- and post-enucleation there was no significant difference observed in the tear volume across the groups. Histopathology of the lacrimal glands from all groups showed preserved lobular architecture with serous acini arranged in lobules, intralobular and interlobular ducts, interstitial fibro collagenous tissue. There was no glandular distortion and atrophy in experimental group. Conclusion: Enucleation do not co-relate or affect the tear volume and lacrimal gland acinar microstructural changes in an anophthalmic socket co-relating to the contralateral normal functional eye.

UR - http://www.scopus.com/inward/record.url?scp=85121952580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85121952580&partnerID=8YFLogxK

U2 - 10.1080/02713683.2021.1945107

DO - 10.1080/02713683.2021.1945107

M3 - Article

C2 - 34138668

AN - SCOPUS:85121952580

SN - 0271-3683

VL - 46

SP - 1816

EP - 1821

JO - Current Eye Research

JF - Current Eye Research

IS - 12

ER -

Shashidhar D, Thangarajan R, Theruveethi N, Bonkuri S. Morphological Changes in the Lacrimal Gland of Anophthalmic Socket in Relation to the Contralateral Normal Eye in Male Wistar Albino Rats: A Histopathology Study. Current Eye Research. 2021;46(12):1816-1821. doi: 10.1080/02713683.2021.1945107